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Oral presentation 5: Drug Discovery Theme

Tracks
Track 1
Monday, December 2, 2024
2:15 PM - 3:45 PM
Eureka Room 1

Speaker

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Prof Darren Creek
Monash University

Chemoproteomics approaches to deconvolute drug targets for novel anti-malarial candidates

2:15 PM - 2:30 PM

Abstract document

Biography

Professor Darren Creek is Director of the Drug Target Identification node of the Monash Proteomics and Metabolomics Facility, and is co-coordinator for the MIPS Global Health Therapeutic Program Area. He completed his B.Pharm and PhD at Monash University in 2007, and has worked in Uganda, Scotland and Australia on malaria drug discovery, clinical trials, and parasite metabolism. He developed new analytical tools for metabolomics, and has used metabolomics and proteomics to discover new metabolic pathways and drug mechanisms, as described in over 150 publications. He has served on the Boards of National and International Metabolomics Societies and was awarded the Inaugural Metabolomics Society Medal in 2019.
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Prof Ross Bathgate
Florey Institute

Structural analysis and Nanobody development on the relaxin receptor, RXFP1.

2:30 PM - 2:45 PM

Abstract document

Biography

Professor Ross Bathgate is the leader of the Neurotherapeutics theme at the Florey Institute and is an Honorary Professorial Fellow in the Department of Biochemistry and Pharmacology at the University of Melbourne, Australia. He is a molecular pharmacologist with broad expertise in bioactive peptides and their G protein-coupled receptors (GPCRs). He has authored over 300 publications, is an inventor on 15 patents and was listed in the 2019 and 2020 world's most highly cited researchers for Pharmacology and Toxicology (Web of Science). He works closely with a number of pharmaceutical companies interested in the clinical development of GPCR-targeted therapeutics.
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Prof Richard Ye
Professor
The Chinese University of Hong Kong

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in active state

2:45 PM - 3:00 PM

Abstract document

Biography

Dr. Richard Ye is a Presidential Chair Professor and Associate Dean of Biomedical Research & Innovation at School of Medicine, The Chinese University of Hong Kong (CUHK) in Shenzhen, China. He received a Ph.D. in cell and integrative biology from Washington University in St. Louis and established his lab at The Scripps Research Institute and University of Illinois, where he worked on gene cloning and pharmacological characterization of formyl peptide receptors. His lab focused on innate immunity and host defense when he joined Shanghai Jiao Tong University as Dean of School of Pharmacy in 2010. In recent years, Prof. Ye’s lab used cryogenic electron microcopy to investigate the structural and functional correlation of G protein-coupled receptors including CXCR4, KSHV-GPCR, succinate receptor 1 and FPR1. He has published more than 230 research papers and is a Clarivate Highly Cited Researcher. Besides lab research, Prof. Ye serves as Associate Editor of Pharmacological Reviews.
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Ms Mariah Stavrou
PhD Student
UNSW Sydney

Bombesin 3 receptor: a novel target for the deadliest cancer

3:00 PM - 3:15 PM

Abstract document

Biography

Mariah is a PhD candidate in A/Prof Nicola Smith's Orphan Receptor Lab at UNSW Sydney. She has been a member of ASCEPT since 2021 and has served on ASCEPT's student committee for 2 years. She has a keen interest in GPCRs, with a focus on taste receptors and the forgotten bombesin receptor, BB3.
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Dr Bradley Hoare
Post Doc
The Florey / The University of Melbourne

HDX-MS studies on the relaxin receptor, RXFP1

3:15 PM - 3:30 PM

Abstract document

Biography

Currently working as Post Doctoral researcher under the leadership of Professor Ross Bathgate. Ongoing projects are centred around understanding signalling bias at the relaxin receptor, RXFP1, as well as general pharmacological investigation of other important GPCR drug targets. Interest include: - GPCR pharmacology, incorporating binding/signalling kinetics and structural biology. - Novel drug discovery - Assay development and optimisation - Resonance energy transfer (eg. BRET, TR-FRET, FRET) and its applications to understanding ligand:receptor and protein:protein interactions. - Using smartphone cameras and BRET to develop diagnostic tests for biomolecules. Please get in touch if you have any interest/expertise at all in this.
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Dr Wessel Burger
Research Fellow
Walter and Eliza Hall Institute of Medical Research

An intracellular lipid pocket at Frizzled receptors regulates transducer activity

3:30 PM - 3:45 PM

Abstract document

Biography

Dr. Burger is an early career researcher who completed his PhD in 2022 at the Monash Institute of Pharmaceutical Sciences, Monash University. In 2023 Dr. Burger moved to WEHI to the lab of Dr Alisa Glukhova. His research is aimed at unraveling the molecular mechanisms of Frizzled signalling, a crucial area of study due to its dysregulation in numerous human cancers. Currently, there is a lack of understanding of the molecular events involved in this process. To address this gap, Dr. Burger employs a combination of cryogenic electron microscopy, biochemistry, and molecular pharmacology techniques.

Chair

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Michaela Kaoullas
Monash University

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Emma Van Der Westhuizen
Senior Research Officer
St Vincent's Institute of Medical Research

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