Keynote presentation 1: APFP keynote
| Sunday, December 1, 2024 |
| 5:30 PM - 6:30 PM |
| Goldfields Theatre |
Details
Traditional medicines are the accumulation of clinical experiences in the long history. Among these traditional medicines, the traditional Chinese medicine (TCM) is important and special with the systemic theory and complete system therapeutic drugs. In the TCM, the drugs used for treatment diseases based on the traditional pharmacology of TCM. Since the 19th century, the TCM has been researched by the methods of modern pharmacology and obtained rich results and important progress in the following aspects.
1. The research of the TCM prescriptions. In TCM, the typical prescriptions include the doctors made for patient clinically, named as Fang(方，prescription) and also called as tang(汤, tang, decoction)，based on the application form. The modern research on the fang of TCM include many roaches with different methods.
(1) Understanding and verification of formula theory.
(2) Research on material basis of drug action.
(3) Study on mechanism of drug action;
(4) Research on new indications aimed at the development of new drugs. (5) Exploration of new theories and their relevance to traditional understanding.
2. The research of single remedy, or the medicinal materials. Based on the ancient and modern pharmaceutical monographs, there are thousands of medicinal materials has been used as drugs in TCM. The modern research of medicinal materials with the development of chemistry. Until now, almost all medicinal materials have been researched and lot of chemicals has been found.
The research strategies include:
(1) Chemical composition analysis, biological activity screening and evaluation of chemical components, pharmacological action research.
(2) Fractions isolated from natural remedy and evaluated there bioactivities.
(3) Formulation granules. Formula granule is a modern application form of traditional Chinese medicine.
3. Research on compounds derived from TCM. The research of compounds derived from TCM mainly focuses on the discovery and evaluation of their activities. Although the long-term application of traditional drugs has accumulated a lot of information about biological activities or pharmacological effects, it still needs a lot of work to prove these effects with modern pharmacological methods.
(1) Discovery of active compounds. After evaluation, a number of compounds with significant activity and good pharmacological effects have been found as drugs in clinical application, such as ephedrine, artemisinin, berberine so on.
(2) Structural modification of active compounds.
(3) The application of active compounds from Chinese medicine, including the crystal form, polycrystalline form or eutectic study of substance existence. Through these studies, the bioavailability of these compounds has been effectively improved, and the pharmacological effects have been better played. The modern pharmacological research of traditional medicine is of great value and significance for interpreting the function of traditional medicine, understanding the characteristics of clinical application, and developing new drugs and new therapeutic methods for treating diseases.
Speaker
Prof Guanhua Du
Peking Union Medical College
Modern Pharmacological research of traditional medicine based on treatment of diseases
Biography
Guanhua Du is a tenured professor of Pharmacology in Peking Union Medical College; Academician of the International Eurasian Academy of Sciences; Former-President of the Chinese Pharmacological Society; Councilor of the Executive Committee of the International Union of Basic and Clinical Pharmacology (IUPHAR), Councilor of the Executive Committee of the Asia Pacific Federation of Pharmacologists (APFP); and Director of National Centre for Pharmaceutical Screening.
Dr. Du got his Ph.D. degree from Peking Union Medical College in 1995, and conducted his postdoctoral research in University of Liege, Belgium from 1995 to 1998. Dr. Du is mainly engaged in drug discovery and development, screening methods and strategy, and drug effect and mechanism research in cerebrovascular and neurodegenerative disease. He originated the national high-throughput drug screening system in China, and provided drug screening services for over 300 million samples for domestic pharmaceutical institutions or enterprises.
In recent 10 years, Dr. Du has published more than 500 papers and more than 30 monographs, and applied for more than 90 patents. He has completed preclinical research of 9 new drugs, among which 3 have been in market, and 6 entered clinical trials. He is the Editor-in-Chief of Pharmacology Research: Modern Chinese Medicine, Associate Editor of Pharmacology & Therapeutics and more than ten other scientific journals.
Chair
Alastair Stewart
Director Of ARC Centre For Personalised Therapeutics Technologies
The University of Melbourne
