Oral presentation 4: Drug Disposition and Response & Toxicology Themes

Tracks
Track 4
Monday, December 2, 2024
9:00 AM - 10:30 AM
Courtyard Room 1&2

Speaker

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Prof Andrew Somogyi
Professor In Clinical Pharmacology
The University of Adelaide

Does noroxycodone counter oxycodone analgesia: evidence from a clinical study

9:00 AM - 9:15 AM

Abstract document

Biography

Andrew Somogyi graduated in Pharmacy from Tasmania and completed a PhD from the University of Sydney (Pharmacy-Anaesthetics). He then undertook postdoctoral clinical pharmacology training in Bonn (Germany) under the guidance of Michel Eichelbaum, and for the past 40 years has been at the University of Adelaide. Apart from teaching in medical, dental, health sciences, nursing and physiotherapy courses, he has an active research programme examining interindividual variation in drug response through clinical pharmacokinetic, pharmacodynamic and outcomes studies underpinned by pharmacogenomics. His current research covers the fields of acute postoperative and cancer pain and psychiatry with a specific focus on ketamine and opioids and, HIV therapy in Papua New Guinea. He is a contributing member of the Clinical Pharmacogenetics Implementation Consortium (CPIC) and an honorary fellow of the Faculty of Pain Medicine (FFPMANZCA), a Fellow of the British Pharmacological Society and an ASCEPT Fellow.
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Prof Robyn Meech
Professor In Pharmacology
Flinders University

Intratumoral drug metabolism: does it affect anti-cancer drug efficacy?

9:15 AM - 9:30 AM

Abstract document

Biography

Dr. Meech is a molecular pharmacologist and cell biologist who trained at Flinders University and the Scripps Research Institute. She has extensive expertise in drug metabolic enzymes (DME) and their roles in endogenous metabolic homeostasis and drug/xenobiotic response. She also has a background in developmental and stem cell biology. Much of her current work focusses on cancer biology and treatment. Ongoing projects study the role of DMEs in regulating levels of small molecules involved in cancer initiation and progression. These processes, including lipid and steroid signaling involve effectors such as nuclear receptors that may recapitulate developmental pathways within the cancer cells, including stemness. She is also exploring models to study the role of intratumoral drug metabolism in acquired resistance to anti-cancer drugs. These projects span a number of cancer types including breast, prostate and colon.
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Miss Danni Li
Phd Student
The University of Melbourne

Entry and impacts of effective cystic fibrosis drug Elexacaftor/Tezacaftor/Ivacaftor on fetal cortex

9:30 AM - 9:45 AM

Abstract document

Biography

Danni Li is a PhD student with Dr Elena Schneider-Futschik in the Department of Biochemistry and Pharmacology at the University of Melbourne. As a first-year PhD student, she has published 3 manuscripts as first author and has contributed to >5 conferences abstracts. Work conducted by her, has led to national and international grant success including funding from the US Cystic Fibrosis Foundation and Cure4CysticFibrosis in 2023. Danni has received awards including being named on the Dean’s Honours List. Furthermore, she is supported by the University of Melbourne Research Scholarship and CFWA Post Graduate Top Up Scholarship.
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Ms Siobhonne Breen
Monash University

Ceftolozane/tazobactam plus meropenem against ST235-clone Pseudomonas aeruginosa isolates in hollow-fibre infection model (PAGANZ)

9:45 AM - 10:00 AM

Abstract document

Biography

Siobhonne Breen is a PhD candidate at the Monash Faculty of Pharmacy and Pharmaceutical Science, rationally optimising antibiotic combinations against resistant bacterial 'superbugs'. Siobhonne's project encompasses a range of laboratory work as well as mechanism-based mathematical modelling, both of which she has a strong interest in. Siobhonne has a passion for improving patient outcomes through drug research and development. Siobhonne has won multiple poster presentation awards and received oral presentations at international and national conferences.
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Miss Annabelle Chidiac
PhD Candidate/Pharmacist
The University of Sydney

Longitudinal linkage of hospitalised paracetamol poisoning in NSW using the PAVLOVA cohort

10:00 AM - 10:15 AM

Abstract document

Biography

Annabelle Chidiac is a pharmacist and a PhD candidate in the School of Pharmacy at The University of Sydney. After completing her honours project on lithium toxicity in adults she has gone on to participate in various projects observing the occurrence and impact of poisoning in Australia. Her current thesis aims to look at paracetamol poisoning in an effort to identify at risk populations and reduce its occurrence.
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Dr Slade Matthews
Senior Lecturer
The University of Sydney

Active Learning for hERG Risk Modelling in Drug Development

10:15 AM - 10:30 AM

Abstract document

Biography

Slade Matthews is a researcher and educator whose career has been marked by his dedication to the intersection of biomedical science and machine learning. He is committed to fostering mathematical literacy among students and has made contributions to both research and education in the field. He holds two teaching awards for university teaching. Recognizing the importance of effective pedagogy, Slade completed a Graduate Certificate in Higher Education in 2011. He has a Bachelor of Medical Science, Honours (1995) which included an investigation into the venom of the Australian copperhead snake using classical pharmacological bioassays, chromatography, and electrophysiology. His doctoral research (PhD 2007) focussed on the integration of machine learning techniques for cell classification tasks and modelling relationships in clinical data. Slade's primary research focus centres on the fusion of experimental design, statistical analysis, and machine learning to investigate biomedical problems, especially in toxicology. He has published 43 publications in peer-reviewed journals and has been cited 1275 times.

Chair

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Katie Burns
The University of Auckland

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Dominika Fuhs
Phd Student
Monash University

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