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Symposium 5: Targeting bacterial ‘superbugs’: From ward to lab

Tracks
Track 1
Tuesday, December 3, 2024
11:15 AM - 1:15 PM
Eureka Room 1

Details

Antimicrobial resistance is a major global challenge, in particular in Asia. Effective antimicrobial agents are essential for saving lives and mitigating the impact of pandemics. Antimicrobial pharmacology plays a pivotal role in the treatment of bacterial infections. As microbes evolve and develop resistance to existing treatments, ongoing research in antimicrobial pharmacology and drug discovery are critical to stay ahead of emerging threats. The symposium covers how this pivotal field addresses immediate health concerns and contributes to public health by preserving the efficacy of existing treatments and discovering new therapeutics, ensuring a sustainable approach to managing infectious diseases in the long term. Specifically, (1) How does genomics play a significant role in advancing antimicrobial therapy in the clinical setting? (2) Why is antimicrobial PK/PD critical for tailoring treatment regimens to maximize efficacy, minimize resistance, and optimize patient outcomes? (3) What are the challenges in antibiotic R&D and how to integrate chemistry, biochemistry, microbiology, and systems pharmacology to develop new antibiotics? (4) What have we achieved in optimising the clinical use of antimicrobials, a critical and ongoing challenge in healthcare? Overall, this stream covers the recent multidisciplinary efforts to prevent the development of antimicrobial resistance.


Speaker

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Prof Benjamin Howden
Doherty Institute

Genomics in advancing antimicrobial therapy in the clinical setting

11:15 AM - 11:45 AM

Biography

Professor Benjamin Howden is Director of the MDU Public Health Laboratory and Co-Director of the Centre for Pathogen Genomics at the University of Melbourne (Doherty Institute) in Melbourne. He is a leader in pathogen genomics and antimicrobial resistance research at the public health and clinical interface. He also leads capacity and capability building programs and research in these fields, focussed in the Asia Pacific Region.
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A/Prof Cornelia Landersdorfer
Monash University

Tailoring antibiotic dosing regimens to maximize efficacy and minimize resistance by use of dynamic in vitro infection models and PK/PD approaches

11:45 AM - 12:15 PM

Abstract document

Biography

Cornelia Landersdorfer, PhD, is an Associate Professor at the Monash Institute of Pharmaceutical Sciences, Monash University in Melbourne. She trained in clinical PK studies, bioanalysis, PK/PD modelling and microbiological studies in Germany, Australia and the USA. She leads a research group that integrates dynamic in vitro infection experiments with mechanism-based mathematical modelling to optimise dosing of antibiotics and other drugs. Her group performs the design and analysis of clinical and preclinical population PK studies. She is the Academic Deputy Director of the Monash-Moderna Quantitative Pharmacology Accelerator (MMQPA) which is focused on driving advancements in mRNA medicines. She has >140 peer-reviewed publications, and received the Georgina Sweet Award for Women in Quantitative Biomedical Sciences (2018), the Future Leader Award (2016) and Research Impact Award (2020) in the Faculty of Pharmacy and Pharmaceutical Sciences (#2 worldwide, QS world ranking), a 2022 Australian Award for University Teaching, and the 2023 Monash Graduate Supervisor of the Year award. Invited conference presentations include the European Congress of Clinical Microbiology and Infectious Diseases and American Society of Microbiology Microbe congress. Her research is supported by NHMRC, ARC, NIH and pharmaceutical industry, and has impacted on dosing guidelines and patient therapy internationally.
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Prof Tony Velkov
Monash University

Structure activity relationships VS. structure-toxicity relations: a key battle in the design of lipopeptide antibiotics

12:15 PM - 12:45 PM

Abstract document

Biography

A/Prof Velkov is a world leading expert in several aspects of antibiotic pharmacology, including their mode of action, chemistry, structure-activity relationships and toxicity. His innovative research is encompassed by complementary and integrated streams that encompass the ‘lab bench to bedside’ doctrine and efficiently translate his multidisciplinary research to clinical practice and pharmaceutical products. Specifically, A/Prof Velkov’s team has been highly engaged in research across the following fields: (1) Pharmacology, chemical biology and structure-activity relationships (SAR) of lipopeptide and teixobactin antibiotics; (2) Novel antibiotic resistance mechanisms; (3) Pharmacology and neurotoxicology of polymyxin antibiotics; (4) Development of novel resistance-resistant teixobactin depsi-peptide antibiotics as dry powder and hydrogels formulations for the treatment of multi-drug resistant lung and wound infections; (5) Development of synergistic polymyxin-nonantibiotic combinations against Gram-negative ‘superbugs’.
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A/Prof Lay Hoon Andrea Kwa
Deputy Director (research & Innovation)
Singapore General Hospital

Optimising the use of antimicrobials in patients – what have we achieved?

12:45 PM - 1:15 PM

Abstract document

Biography

Dr Andrea Kwa, a distinguished pharmacist clinician -scientist, has had a remarkable journey fueled by her curiosity. She excels in translational science, where she conducts evidence-based research and translate discoveries into practical applications, ensuring top-tier patient care. She specialised in critical care medicine, infectious diseases, and antimicrobial resistance research, specifically in in-vitro wet bench translational (phage therapy, antibiotics combination testing), population PKPD studies, molecular diagnostics in anti-fungal and antibacterial resistance, epidemiology/outcomes studies and health services research (specifically AI/ML for AMR management) to guide antimicrobial stewardship. To date, she has authored more than 120 publications.

Chair

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Lay Hoon Andrea Kwa
Deputy Director (research & Innovation)
Singapore General Hospital

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Jian Li
Monash University

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