Symposium 2: Genetic diversity in drug targets
Tracks
Track 2
Wednesday, December 10, 2025 |
11:00 AM - 1:00 PM |
Details
Genetic diversity within different populations plays an important role in both novel drug target and novel medicine discovery, from the viewpoint of understanding fundamental biology and in advancing personalised medicine. From a biological standpoint, genetic variability among individuals reveals how different genes and pathways can contribute to disease processes. By appreciating and studying this diversity, we can enhance our understanding of how populations respond to existing drugs, and can also uncover novel drug targets or new ways of targeting validated targets.
This symposium aims to address how a deeper understanding genetic diversity is essential for tailoring treatments to individual genetic profiles. Variations in genes involved in drug metabolism, efficacy, and toxicity can significantly affect patient outcomes. Recognizing and incorporating this diversity into all stages of drug development improves safety and efficacy, reduces adverse effects, and increases the likelihood of treatment success. Furthermore, focusing on underrepresented populations in genetic research expands the therapeutic landscape, ensuring equitable healthcare and uncovering targets that might be missed in homogeneous study cohorts. Overall, investigating and understanding genetic diversity deepens our understanding of human physiology and pathophysiology and enhances both the precision and inclusiveness of modern medicine.
Speaker
A/Prof Daniel Thomas
University of Adelaide
New therapeutics from neo-epitope sequences for myelofibrosis
Biography
Grace Cumbers
PhD student
University of Sydney
Development of radiotracers for TSPO polymorphisms
Biography
Prof Mary Collins
University of Sydney
Patients carrying epilepsy-causing variants in GABAA receptors require treatments based on a precision medicine approach
Biography
Dr John Scott
Senior Research Fellow
Monash Institute of Pharmaceutical Sciences
Mutations in disease related kinases: implications for drug discovery
Biography
Dr Scott’s primary research interest is on understanding the kinase signaling pathways that regulate mood and behavior in response to hormones and metabolites that signal changes in energy availability. His research is specifically focused on the control of the CaMKK2 pathway, which is a regulator of brain function and whole-body energy metabolism. Loss-of-function mutations in CaMKK2 are linked with bipolar disorder and schizophrenia in humans. A major goal of Dr Scott’s research is to validate CaMKK2 as a rational treatment target for mood and related psychiatric disorders, and he has established international collaborations with academic and industrial partners to develop new drugs that target CaMKK2.
Dr Scott graduated with a Bachelor of Science (Hons) from the University of Glasgow and a PhD in Biochemistry from the University of Dundee funded by a prestigious Wellcome Trust Prize scholarship, after which he moved to Melbourne to undertake postdoctoral studies with Prof Bruce Kemp AO at St Vincent’s Institute of Medical Research (SVIMR). Dr Scott is currently a Senior Research Fellow and Group Leader at Monash Institute of Pharmaceutical Sciences (MIPS) and an Honorary Senior Research Fellow at the Florey Institute of Neuroscience and Mental Health. He also holds a Senior Research Associate appointment at SVIMR. His research team uses a wide range of techniques including biochemistry, cell biology, protein crystallography, mass spectrometry, and genetically modified mouse models to decipher the role of the CaMKK2 pathway in the regulation of brain function and whole-body metabolism in health and disease.
Chair
Pramod Nair
Senior Research Fellow in Computational and Molecular Pharmacology
Flinders University
Eryn Werry
Senior Lecturer in Brain and Mind Sciences and Research Associate in Drug Discovery
The University Of Sydney
