Header image

Symposium 6: From Trial-and-Error to Precision: Pharmacogenomic-Guided Medication Use in Mental Health Care

Tracks
Track 2
Thursday, December 11, 2025
11:00 AM - 1:00 PM

Details

Prescribing of psychotropic medications for mental health diagnoses has long been a “trial-and-error” approach guided by broad guideline recommendations, clinical indicators, and, subsequently, patient response and tolerability to treatment. Many patients require several trials before finding an effective medication they can tolerate. This approach oftentimes results in a delay in the control of symptoms or exposes patients to intolerable side effects. Pharmacogenomic testing provides a strategy to improve the likelihood of choosing safe and effective psychotropic medications. This session will focus on the experiences and preliminary outcomes from landmark clinical trials evaluating the clinical utility of pharmacogenomic-guided prescribing of medications used to treat mental health conditions in Australia. It will also cover practical aspects of implementing pharmacogenomic testing such as adequacy of the test/reports and the economic value of testing.


Speaker

Agenda Item Image
A/Prof Kathy Wu
St Vincent’s Hospital, Sydney

Translating pharmacogenomics and precision dosing in major depressive disorder: the ALIGNED study

Abstract document

Biography

A/Professor Kathy Wu is the founding Head of St Vincent's Clinical Genomics, a HGSA-certified Clinical Geneticist, physician scientist, and educator. Kathy is a senior staff specialist at St Vincent’s Public & Private Hospitals and St Vincent’s Clinic, with academic affiliations with the UNSW, University of Sydney, University of Notre Dame Australia, the Garvan Institute of Medical Research, and the George Institute for Global Health. Kathy is committed to translating genomics research to inform precision healthcare and improving individual and categorical patient outcomes. Kathy is one of the clinician pioneers in Australia to lead a real-world pharmacogenomics implementation body of research and has been awarded $6 million+ in MRFF Research Grants since 2020 to continue her passion in pharmacogenomics research to improve treatment outcomes for people with Major Depressive Disorder.
Agenda Item Image
Dr Sibel Saya
Senior Research Fellow
The University of Melbourne

The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind RCT of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care

Abstract document

Biography

Dr Saya is a senior research fellow and an academic genetic counsellor at the University of Melbourne Department of General Practice and Primary Care. Dr Saya's expertise is the implementation and translation of genetic and genomic tests into primary care and general practice and the conduct of clinical trials in this field.
Agenda Item Image
A/Prof Luke Hesson
Department manager - Genetics
Douglass Hanly Moir Pathology

The science of delivering pharmacogenomic test results to guide prescribing in Australia

Biography

Professor Luke Hesson is a Clinical Scientist with a Ph.D in Clinical Genetics and is a Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia (RCPA). He is Department Manager of Genetics at Douglass Hanly Moir Pathology, and provides scientific supervision of genetic testing including pharmacogenomics and comprehensive genomic profiling for cancer. He is affiliated with University of Technology Sydney where he lectures in genetics, epigenetics, cancer, molecular pathology and precision medicine. Luke is Chair of the Australasian Society for Diagnostic Genomics (ASDG) and co-Chair of the RCPA Pharmacogenetic Advisory Group, which recently provided guidance for prescribers, pharmacologists and pathologists regarding clinical indications for pharmacogenomics testing in Australia.
Agenda Item Image
Prof Christine Lu
Clinical Chair of Pharmacy, Royal North Shore Hospital
University Of Sydney

The value proposition: Is pharmacogenomic-guided prescribing of medicines to treat mental health conditions economically sound?

Abstract document

Biography

Christine Lu, MSc, PhD is a Professor at the Sydney Pharmacy School and Chair of Clinical Pharmacy at Northern Sydney Local Health District. A pharmacist, health policy scientist, and pharmacoepidemiologist, she holds an MSc in Biopharmaceuticals and a PhD from the University of New South Wales. Dr. Lu completed her postdoctoral training at Harvard Medical School, where she later served as Associate Professor at both Harvard Medical School and the Harvard Pilgrim Health Care Institute before joining the University of Sydney. Internationally recognised for her impactful research, Dr. Lu’s work addresses critical clinical pharmacy and health system challenges. Her research focuses on: 1. The effects of health policies and programs on medication use and outcomes; 2. Access to and quality use of pharmacogenomic testing and genomic sequencing; and 3. The use, access, and outcomes of high-cost medicines. • Academic Profile: https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/christine-lu.html

Chair

Agenda Item Image
Sam Mostafa
Clinical Director
myDNA Life Australia

Agenda Item Image
Sophie Stocker
The University Of Sydney

loading