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Spotlight on discovery science

Thursday, November 28, 2024
9:30 AM - 10:30 AM
Blackwattle Bay Room 1 & 2, Level R

Speaker

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A/Prof Tracey Gaspari
Researcher
Monash University

Expanding our knowledge on the RAAS – Identification of IRAP as a novel target for treatment of cardiovascular disease

9:30 AM - 9:50 AM

Biography

Tracey Gaspari leads the IRAP Pharmacology Lab and holds a continuing teaching and research appointment in Dept of Pharmacology, Monash University. She is internationally recognised as a cardiovascular pharmacologist in the field of RAS biology/pathophysiology. Tracey pioneered the novel concept of targeting the enzyme, Insulin Regulated Aminopeptidase (IRAP) in cardiovascular disease, with a focus on fibrotic and vascular diseases. Her ground breaking work resulted in granting of a method of use patent (>5 countries, incl US) on IRAP inhibitors in fibrotic diseases. She is a co-founder of the spinout company, Inosi Therapeutics, backed by investment from IP Group and Monash Investment Holdings. Inosi Therapeutics is focused on the development of first-in-class, orally active IRAP inhibitors to treat difficult-to-reverse fibrosis. In collaboration with Inosi and the other co-founders, Tracey led the team that was successful in receiving an MRFF Targeted Translation Research Accelerator (TTRA) grant to develop IRAP inhibitors to treat diabetes-induced renal and cardiovascular disease. Her research continues to explore ways in which targeting IRAP can be beneficial in multiple inflammatory and fibrotic diseases.
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Dr Chengxue Helena Qin
Scientist
Cardiovascular Pharmacology, Monash Institute of Pharmaceutical Science, Monash University, Melbourne, Australia

Innovative Mechanisms in Hypertension: Harnessing Inflammation Resolution Pathways

9:50 AM - 10:10 AM

Abstract:

The active resolution of inflammation is critical for maintaining tissue homeostasis and promoting repair in cardiopulmonary pathologies. Insufficient resolution can lead to chronic inflammation, disrupted cellular equilibrium, and maladaptive tissue remodeling, contributing to the progression of hypertension and other cardiopulmonary diseases. Pro-resolving G-protein-coupled receptors (GPCRs), particularly formyl peptide receptor 2 (FPR2) and its endogenous ligand annexin-A1, have emerged as key regulators in the inflammatory resolution process. This presentation will highlight recent therapeutic advancements targeting FPR2 and its molecular pathways to actively resolve inflammation. As a promising therapeutic target, FPR2 modulation offers therapeutic potential for mitigating pathological tissue remodeling and preventing the progression toward end-stage organ failure in cardiopulmonary diseases. Our research aims to unravel the evolving pharmacology of FPR2, recognizing its transition from a secondary chemotactic receptor to a pivotal modulator of inflammation resolution. These insights open new avenues for the development of 'pro-resolving' therapeutic strategies, particularly in the context of hypertension and cardiopulmonary disease management.

Biography

Laboratory Head in Cardiovascular Pharmacology at Monash Institute of Pharmaceutical Sciences, Monash University, National Heart Foundation Future Fellow and Monash Talent Accelerator Fellow. MRFF REDI Industry Fellow Alumni and Baker Fellow Alumni. Dr Qin also plays an integral role on the Board of Directors of the Australasian Pharmacologists and Toxicology Society, the Global Academic Drug Discovery Consortium, and Co-lead MIPS Cardiometabolic Therapeutic Area. Dr Qin is an emerging leader in translational pharmacology, driven by a visionary pursuit to develop "pro-resolving medicines" for treating cardiopulmonary diseases, one of the leading causes of death globally. She has published >70 peer-reviewed papers in top journals such as Nature Communications, Circulation, Cardiovascular Research, and the British Journal of Pharmacology. She has secured $9M in competition funding including the Australian National Health and Medical Research Council, National Heart Foundation, Diabetes Australia etc. Her outstanding leadership and scholarly achievements have been recognized through the receipt of >20 prestigious awards, including the Hypertension Australia Mid-Career Award (2023), Future Research Leader (2020), and the Asian Australian Leadership Award (2019), Cardiac Society Ralph Reader (2016). For more information, please visit: https://www.monash.edu/mips/themes/drug-discovery-biology/labs/cardiovascular-pharmacology.
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Dr Joanne O'Donnell
Scientist
Monash University

Does the gut contribute to the activation of the immune system in hypertension?

10:10 AM - 10:30 AM

Biography

Dr O'Donnell is an NHMRC Early Career Research Fellow in the Hypertension Laboratory, Monash University, with A/Prof Francine Marques. She completed her PhD at WEHI, Melbourne, and post-doctoral studies at the University of Massachusetts Medical School, Boston, where she studied the interplay between cell death, immune cell activation and autoimmune disease. Her research focuses on understanding the interplay between the gut microbiome and the immune system during cardiovascular disease.
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