Monday, September 22, 2025

2:00 PM - 3:30 PM

Grand Copthorne Waterfront Hotel - Grand Ballroom I

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Details

The aim of this symposium in to highlight the duality between a required immunosuppression in solid organ transplant recipients and the associated risk of infection. The symposium will first decipher the alteration of drugs PK and PD during infections in transplant patients. Indeed, a lot of pathophysiological modification can change drugs exposure and effect during infections and their mechanism and clinical impact will be highlighted as a first step. Then, the strategies for immunosuppressive dosing adjustment for infection prevention and the latest immunosuppression net state evaluation approach will be presented and the main results on these topics will be discussed. In the second part of the symposium, a comprehensive overview will be provided to the audience regarding therapeutic drug monitoring and dosing adjustments of immunosuppressive and anti-infective drugs in two clinical situations: bacterial infections, in particular when antituberculous drugs has to be used, and viral infections with a special focus on cytomegalovirus and COVID-19 and their treatment interplay with patient’s immunosuppressive therapy.