SYMPOSIUM 17: Dangerous liaisons: an interactive navigation into the antifungals DDI risk
Tracks
Track 1
| Wednesday, September 24, 2025 |
| 10:30 AM - 12:00 PM |
| Grand Copthorne Waterfront Hotel - Grand Ballroom I |
Details
The aim of this workshop is to provide the audience with interactive discussions around drug-drug interactions (DDI) situations with the antifungal drugs. Questions will be asked to the audience using a poll system and the following topics will be highlighted: difference between DDI potential with different antifungals, particularity of interaction on specific pathways, impact of drug administration modalities on the effect of DDI, concentration-inhibition effect, and effect of genotype on DDI. The principles of DDI identification, pre-emptive drug dosage adjustments and therapeutic drug monitoring role to prevent adverse drug reactions in the context of a DDI situation will be described.
The symposium will be set-up in three talks: the first entitled “The Usual Suspects: classic DDI with antifungal drugs (azoles, echinocandines and liposomal amphotericin B) and how to avoid/act on them; the second “Lost in translation: a presentation on some controversial DDI examples” aiming at making the audience aware of these DDI and the last one “Deep impact: the role of inflammation and genetics on antifungal DDI”, where the modulation of DDI by these extrinsic and intrinsic factors will be discussed with the audience.
Speaker
Mr Andre Wieringa
Isala Hospital
The Usual Suspects: the classic DDI with antifungal drugs
Biography
Andre Wieringa is hospital pharmacist and clinical pharmacologist and trainer of clinical pharmacology in a large teaching hospital in Zwolle, the Netherlands. In the Erasmus University Medical Center he is conducting research as PhD candidate in optimising anti-infective medication in critically ill patients, specialising in 1. Pharmacokinetic (PK) studies in patients undergoing continous renal replacement therapy and 2. developing PK/PD models which can identify critically ill patients at risk of target non-attainment for Beta-lactam antibiotics and ciprofloxacin on the ICU.
Pharmacy Department, St. Vincent's Hospital Fay Burrows
Lost in translation: a presentation on some controversial DDI examples
Biography
Haifa Lyster
Royal Brompton & Harefield Hospitals, part of Guy’s & St Thomas’ NHS Foundation Trust
Deep impact: the role of inflammation and genetics on antifungal DDI
Biography
Session chair
Florian Lemaitre
Rennes University Hospital
Isabel Spriet
University Hospitals Leuven
