Keynote Address: Toxic disposition modelling - TDM2
| Tuesday, September 23, 2025 |
| 9:15 AM - 10:00 AM |
| Grand Copthorne Waterfront Hotel - Grand Ballroom I |
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Sponsored By:
The University of Sydney
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Overview
Prof Nicholas Buckley The University of Sydney
Speaker
Prof Nicholas Buckley
The University of Sydney
Toxic disposition modelling - TDM2
Abstract
Targets for a clinical toxicologist treating acute poisonings are very different from targets in therapeutic drug monitoring.
Drug concentrations and other biomarkers are answering urgent questions around risk and the need for critical care monitoring, antidotes and invasive treatments. The dose and timing is often unknown, absorption is often incomplete, kinetics are often non-linear, and toxicity only loosely relates to the measured concentration for agents with delayed toxicity. This talk will focus on research on lithium, paracetamol and digoxin toxicity and where research using biomarkers is now changing long established practice and guidelines.
Drug concentrations and other biomarkers are answering urgent questions around risk and the need for critical care monitoring, antidotes and invasive treatments. The dose and timing is often unknown, absorption is often incomplete, kinetics are often non-linear, and toxicity only loosely relates to the measured concentration for agents with delayed toxicity. This talk will focus on research on lithium, paracetamol and digoxin toxicity and where research using biomarkers is now changing long established practice and guidelines.
Biography
Nick Buckley (MD FRACP) is Professor of Clinical Pharmacology at the University of Sydney, a consultant clinical toxicologist at the NSW Poisons Information Centre and RPA Hospital, Chair of the Editorial Advisory Board of the Australian Medicines Handbook, Deputy Editor of Clinical Toxicology, a past President of The Asia Pacific Association of Medical Toxicology, and Research Director of the South Asian Clinical Toxicology Research Collaboration (SACTRC- http://www.sactrc.org). SACTRC does clinical and public health research on pesticides, plant & pharmaceutical poisoning, snakebite, translation into practice, neurotoxicity and kidney biomarkers. In Australia, his research has largely been clinical, epidemiological and pharmaco-epidemiological studies on analgesic and psychotropic drug poisoning & misuse.
His research has attracted continuous project and program funding since 2002 which has resulted in an extensive publication record including 480+ peer reviewed journal articles and 25 book chapters.
Session chair
Christophe Stove
Ghent University
