SYMPOSIUM 12: Personalised dosing at the bedside: Model selection versus model averaging
Tracks
Track 4
| Tuesday, September 23, 2025 |
| 10:30 AM - 12:00 PM |
| Grand Copthorne Waterfront Hotel - Waterfront Ballroom III |
Details
Model-based dosing requires a suitably predictive model. Often, multiple models are available for a given drug, and so the clinician is faced with a decision of how to best treat their patient. In recent years, two approaches have been proposed: (i) model selection, in which one model of several is selected for a given patient and used to inform dose selection, and (ii) model averaging, in which the predictions from multiple models are combined to inform dose selection.
Both model selection and model averaging can be implemented in different ways, ranging from statistical approaches to machine learning algorithms. These approaches come with clinical implementation trade-offs, regulatory differences, and differences in predictive performance. In this symposium, considerations for each approach are explored and compared.
Speaker
Dr Jasmine Hughes
Director Of Data Science
Insightrx
From big data to better dosing: Optimizing patient-specific PK model selection
Biography
Dr Jasmine Hughes is the Head of Clinical Data Science at InsightRX, a San Francisco-based company that makes model-informed precision dosing and clinical analytics software. She received her Bachelor's in Chemical Engineering from McGill University and her PhD in Bioengineering from the University of California, San Francisco and the University of California, Berkeley, and is currently based in Toronto, Canada. Her current research focus is creating and improving models, statistical methods and software tools for improving dose individualization in clinical practice.
Prof Sebastian Wicha
University of Hamburg
Does it need a team to win? Model averaging in model-informed precision dosing
Biography
Dr Nynke Jager
Radboudumc
Using models in clinical practice – How to get there through retrospective and prospective evaluations
Biography
Dr Guangda Ma
University of Auckland
Implementing model-based dosing to improve clinical outcomes: Results of external evaluation of vancomycin popPK models and implementation in a NZ hospital
Biography
Session chair
Iris Minichmayr
Medical University Of Vienna
James Morse
University of Auckland
