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SYMPOSIUM 6: Towards integration of Pharmacogenetics and Therapeutic Drug Monitoring in Oncology Practice

Tracks
Track 2
Monday, September 22, 2025
2:00 PM - 3:30 PM
Grand Copthorne Waterfront Hotel - Waterfront Ballroom I

Details

Oncology has become the benchmark for the implementation of pharmacogenetics in clinical practice, with examples of successful integration of pharmacogenetic testing to personalize cancer treatment. However, state-of-the-art pharmacogenetics can hardly address the interindividual variability related to cancer treatment, with still a limited number of variants validated for clinical application and genetic diversity that is currently not captured by the approved genetic panels. The use of TDM should be considered to supplement pharmacogenetic profiling of cancer patients to better characterize their phenotype and to consider multiple nongenetic factors that may challenge safe and effective use of anticancer drugs. This symposium will explore the potential of applying pharmacogenetics and metabolic phenotyping for precision anticancer treatment. Some examples of drugs for which an integrated pharmacogenetics and TDM test is already part of clinical practice in some countries will be described. On the other hand, the challenges of extending the implementation of this same approach in ethnically diverse communities will be reported.

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