SYMPOSIUM 6: Towards integration of Pharmacogenetics and Therapeutic Drug Monitoring in Oncology Practice
Tracks
Track 2
Monday, September 22, 2025 |
2:00 PM - 3:30 PM |
Grand Copthorne Waterfront Hotel - Waterfront Ballroom I |
Details
Oncology has become the benchmark for the implementation of pharmacogenetics in clinical practice, with examples of successful integration of pharmacogenetic testing to personalize cancer treatment. However, state-of-the-art pharmacogenetics can hardly address the interindividual variability related to cancer treatment, with still a limited number of variants validated for clinical application and genetic diversity that is currently not captured by the approved genetic panels. The use of TDM should be considered to supplement pharmacogenetic profiling of cancer patients to better characterize their phenotype and to consider multiple nongenetic factors that may challenge safe and effective use of anticancer drugs. This symposium will explore the potential of applying pharmacogenetics and metabolic phenotyping for precision anticancer treatment. Some examples of drugs for which an integrated pharmacogenetics and TDM test is already part of clinical practice in some countries will be described. On the other hand, the challenges of extending the implementation of this same approach in ethnically diverse communities will be reported.
Speaker
Prof Nuala Helsby
Molecular Medicine and Pathology, University of Auckland
Pharmacogenetics and metabolic phenotyping for precision anticancer treatment
Abstract
Much of the recent success of “precision medicine’ in Oncology has been the identification of somatic mutations and development of “targeted” therapies. However, inherited (germline) differences can affect the safety or effectiveness of drugs by altering the metabolic elimination of a drug or by altering the activation of prodrugs. The use of SNP-based genetic biomarkers (pharmacogenetics) to predict metabolism and therapeutic outcome has many advocates. However, there are many layers of regulatory control of genes, as well as environmental and clinical factors which can alter phenotype and influence therapeutic outcomes. My talk will highlight the role of phenotype-based approaches to help understand and clarify whether inherited (pharmacogenetic) risk factors are associated with poor bioactivation of cyclophosphamide and the excessive toxicity of 5-fluorouracil.
Biography
Nuala Helsby (FBPhS) is a Professor in Pathology at the University of Auckland. Her research focus is on understanding how both inherited and environmental factors influence the safe and effective use of drugs. Nuala has more than 35 years of experience in the field of drug metabolism and pharmacogenetics (orcid.org/0000-0001-6570-5368). She has a particular interest in the factors which result in discordance between genotype and phenotype. Her research also focusses on understanding the role of inter-individual variation in the formation of toxic metabolites to improve the safety of drugs in current clinical use. She teaches extensively in the Biomedical Science and Pharmacology programmes and also serves on a number of NZ-based grant assessment panels.
Prof Balram Chowbay
National Cancer Centre Singapore
Tamoxigenomics and monitoring of endoxifen levels to tailor tamoxifen prescription in ER positive breast cancer patients
Biography
Prof Carlo Largiader
Institute of Clinical Chemistry; Bern University Hospital; Inselspital
Pharmacogenetically informed Therapeutic Drug Monitoring of 5-fluoruracil
Biography
Prof Stephen Ackland
University of Newcastle Lake Macquarie Private Hospital, Asia-Pacific Journal of Clinical Oncology
Implementation of pharmacogenetics guided Therapeutic Drug Monitoring in ethnically diverse communities
Biography
Dr. Stephen P Ackland is a senior academic medical oncologist and Professor in the School of Medicine and Public Health, University of Newcastle Australia; Editor-in-Chief, Asia Pacific Journal of Clinical Oncology since 2005; and Director, Australasian GastroIntestinal Trials Group. He is author of >160 peer-reviewed publications in oncology and pharmacology, with a H-index of 39, in subjects ranging from pre-clinical pharmacology and pharmacogenomics to clinical trials and implementation science.
He has previously been Director of Medical Oncology at Calvary Mater Newcastle Hospital; Director of Hunter Cancer Research Alliance; Director and Chairman of ANZ Breast Cancer Trials Group; and Director of Cancer Council NSW. He has participated in many committees of NFP cancer organisations in Australia and elsewhere, including MOGA, COSA, ASCO, Cancer Council, and NSW Office of Health and Medical Research.
As EIC of APJCO he has led a team of 20-30 voluntary Associate Editors in evaluation and acceptance of manuscripts in clinical and translational oncology. This task has become an increasing challenge in this technological and pandemic age.
http://www.newcastle.edu.au/profile/stephen-ackland
Session chair
Erika Cecchin
Centro Di Riferimento Oncologico Di Aviano
Ganessan Kichenadasse
Flinders University
