Symposium 27: Getting the paracetamol dose right for very preterm neonates with patent ductus arteriosus
Tracks
Track 3
| Friday, July 17, 2026 |
| 11:15 AM - 1:15 PM |
Details
Despite an increased emphasis on the safe and effective use of drugs in the paediatric population, rational dosing in neonates remains challenging. Drug doses are often scaled inappropriately from the adult population and the immaturity of organ function during early life is rarely accounted for. The impact of birth on drug clearance in the first few weeks of life remains a critical knowledge gap while a lack of labelling guidance creates uncertainty for prescribers. This symposium highlights the utility of pharmacometrics as a tool to support rationale dose selection in term and preterm neonates, ensuring the safe and effective use of drugs in this vulnerable population.
Speaker
Assoc Prof Jacqueline Hannam
The University of Auckland
Getting the dose right for our smallest patients: a role for pharmacometrics
Biography
Jacqui is Associate Professor at the University of Auckland, from the Auckland Pharmacometrics Group. Her research interests in pharmacometrics, modelling biomarkers, dosing for special populations such as neonates, and anaesthesia.
Dr James Morse
Lecturer
University Of Auckland
Maturation Models in Practice: Why Observations across the Lifespan Better Describe Clearance Maturation
Biography
Dr James Morse is a Lecturer in the Department of Pharmacology and Clinical Pharmacology at the University of Auckland, New Zealand. He completed his PhD in pharmacometrics, with a thesis focused on population pharmacokinetic pharmacodynamic modelling to improve anaesthesia practice in children and adults.
His research centres on optimising anaesthetic and analgesic drug dosing across all age groups, from neonates to adults, using pharmacometric methods. His key interests include target-controlled infusion anaesthesia, maturation pharmacokinetics and the influence of body composition on drug dosing in anaesthesia.
Assoc Prof Daniel Wright
The University of Sydney
Getting the paracetamol dose right for very preterm neonates with patent ductus arteriosus
Biography
Dan Wright is an Associate Professor in Clinical Pharmacy at the University of Sydney. His research interests span clinical pharmacology, pharmacometrics, and medication adherence. He has expertise in modelling and simulation and the quantitative analysis of medication adherence data. His research platform aims to enhance the quantitative understanding of how drug treatments impact human biology and to explore the sources of variability in drug response between individuals. He uses this information to improve outcomes for patients through individualised dosing. Dan conducts research across several therapeutic areas notably cardiology, nephrology, transplant medicine and rheumatology.
Miss Jia Li
Monash University
Dose Optimisation of Anakinra in Preterm Neonates using Mechanistic Population Pharmacokinetic Approaches
Biography
Jia Li is a PhD candidate at the Centre for Medicine Use and Safety, Monash University. Her research focuses on model-informed drug development of anakinra in preterm neonates, including population pharmacokinetic (PPK), physiologically based pharmacokinetic (PBPK), and pharmacokinetic/ pharmacodynamic (PPK/PD) modelling approaches. Her work integrates the unique physiological characteristics of premature neonates to optimize dosing strategies and support clinical development. Jia holds a Bachelor’s degree in Pharmacy and a Master’s degree in Medicinal Chemistry. She has diverse experience across academia and the pharmaceutical industry, including roles as a manager coordinating preclinical and clinical studies in autoimmunology and oncology, and a researcher investigating the pathogenesis of neurodegenerative diseases.
Ms Megan Clark
Monash University
The current landscape of neonatal population pharmacokinetic models
Biography
Megan Clark is a PhD candidate and clinical pharmacist specialising in neonatology, with over a decade of experience in neonatal intensive care. Since 2020, she has led her organisation’s neonatal clinical pharmacy service and contributed to the national standard of practice for Women’s and Newborn Health pharmacists through Advanced Pharmacy Australia’s Women’s and Newborn Health Leadership Committee.
Her work in developing neonatal emergency medication resources and pharmacy services for high-risk pregnancies has been recognised with the William Mercer Young Achiever Award and the Society of Hospital Pharmacists of Australia Early Career Pharmacist of the Year Award (both 2021).
Megan’s PhD focuses on population pharmacokinetics in preterm and term neonates, using real-world data to optimise medication use and improve outcomes in this vulnerable population.
Session chair
Hesham Al-Sallami
College of Pharmacy, QU Health, Qatar University
Jacqueline Hannam
The University of Auckland