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Symposium 10: Resolution Pharmacology: From Basic Science to Translational Medicine

Tracks
Track 2
Wednesday, July 15, 2026
11:15 AM - 1:15 PM

Details

The acute inflammatory response is protective, defending the host against infection or injury. Ideally, it is self-limited, spatially and temporally controlled, with its resolution actively coordinated by endogenous agonists to restore tissue homeostasis. These agonists include specialized pro-resolving mediators (SPMs), signaling lipid molecules, and pro-resolving proteins like annexin A1, which collectively drive anti-inflammatory and pro-resolving actions. However, when inflammation is left unchecked, it can become chronic, driving diseases such as respiratory, cardiovascular, metabolic, and allergic conditions, as well as arthritis. This symposium will explore the pivotal role of unresolved inflammation in these diseases and highlight the latest therapeutic advances. Alongside SPMs, we will discuss emerging therapeutic innovations, including annexin-A1 mimetic peptides and FPR small-molecule agonists (e.g. BMS-986235, biased agonist Compound 17b). These innovative therapies not only promote inflammation resolution but also enhance SPM production, representing promising strategies for treating chronic inflammatory diseases.


Speaker

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Prof Ganesh Halade
University of South Florida

Inflammation and Resolution Signaling in Ischemic and Non-Ischemic Heart Failure

Abstract

Biography

Dr. Ganesh Halade is professor in the department of Internal Medicine, Heart Institute, University of South Florida, a leading cardiovascular scientist with internationally recognized expertise in inflammation-resolution biology, heart failure, and cardiometabolic disease. Currently, his research focuses on the role of lipid mediators, immune cell dynamics, colorectal cancer, and lifestyle factors in cardiac repair and aging. His innovative work has advanced the understanding of the role of immune responsive lipoxygenase in specialized pro-resolving mediators (SPMs) biosynthesis and their impact on inflammation and heart failure, particularly in obesity-related conditions. He has authored more than a hundred peer-reviewed publications and is an active contributor to the global scientific community. He serves as a grant reviewer for the U.S. National Institutes of Health (NIH), as well as for several international funding agencies, contributing his expertise to the evaluation of biomedical research worldwide. Dr. Halade is also a member of editorial board for American Journal of Physiology-Heart and Circulatory Physiology.
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Dr Jianmin Chen
Queen Mary University of London

FPR2-Driven Resolution: A Novel Approach to Cardiomyopathy in Inflammatory Arthritis

Abstract

Biography

Dr Jianmin Chen is a Lecturer in Inflammation and Cardiovascular Medicine and a Versus Arthritis UK Career Development Fellow at the William Harvey Research Institute, Queen Mary University of London. Her research focuses on deciphering the cellular and molecular mechanisms of heart failure driven by acute or chronic inflammation, including in autoimmune conditions such as rheumatoid arthritis. She is particularly interested in how inflammation disrupts cardiac metabolism and how this knowledge can inform the development of novel therapies. Dr Chen holds a Doctorate in Clinical Medicine from Sichuan University (2012) and completed her PhD in Cardiovascular Pharmacology at Queen Mary University of London (2012–2016), where she studied the pathophysiology and experimental treatment of sepsis-induced cardiac dysfunction. She has since applied her cardiovascular expertise to chronic inflammatory diseases, leading research into arthritis-associated cardiomyopathy. Her contributions have been recognised through numerous awards, including the Bülbring Award from the British Pharmacological Society, the European New Investigator Award from the European Shock Society, and the WHRI New Investigator Award. She has also received the William Harvey Medal and Best Oral Presentation Prize, as well as multiple national and international travel awards. In 2022, she was awarded the prestigious Career Development Fellowship by Versus Arthritis UK.
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Dr Chengxue Helena Qin
Monash University

Innovative Mechanisms in Vascular Biology: Harnessing Pathways of Inflammation Resolution

Biography

Laboratory Head in Cardiovascular Pharmacology at Monash University, currently holding the prestigious positions of National Heart Foundation Future Fellow and Monash Talent Accelerator Fellow. Upon completing her PhD at the Department of Pharmacology & Therapeutics and the School of Chemistry (University of Melbourne), Dr. Qin advanced her career with a post-doctoral position at the Baker Institute in 2011. Recognizing her talent and leadership, she was subsequently recruited to establish her independent laboratory within the Drug Discovery Biology Theme at the Monash Institute of Pharmaceutical Sciences in 2019. Previously, she served as an MRFF REDI Industry Fellow and Baker Fellow. Dr. Qin also plays an integral role on the Board of Directors of the Australasian Pharmacologists and Toxicology Society, the Global Academic Drug Discovery Consortium, and the Australian Cardiovascular Alliance Emerging Leader (Industry Engagement portfolio). Dr. Qin is an emerging leader in translational pharmacology, driven by a visionary pursuit to develop "pro-resolving medicines" for the treatment of cardiopulmonary diseases, one of the leading causes of death globally. Her research team is dedicated to pioneering innovative "pro-resolving" therapies, primarily focusing on advancing the pro-resolving GPCRs (e.g. FPR2) R&D program to bridge scientific discoveries with impactful clinical solutions. Dr. Qin's expertise spans molecular and integrative pharmacology, rational drug design, and the intricacies of commercialization. Her scholarly contributions have been featured in prestigious journals such as Nature Communications, Cardiovascular Research, Circulation, British Journal of Pharmacology, Journal of Medicinal Chemistry, and Pharmacology & Therapeutics etc. Dr. Qin has secured substantial research funding from prestigious organizations including the National Health and Medical Research Council, National Heart Foundation, National Drug Discovery Centre, Diabetes Australia, CASS Foundation, Therapeutic Innovation Australia, JDRF etc. Dr. Qin's outstanding leadership and scholarly achievements have been duly recognized through the receipt of over 20 prestigious awards, including the Hypertension Australia Mid-Career Award (2023), Monash Talent Accelerator Fellow (2023), MRFF-Industry Fellow (2021), Future Research Leader (2020), and the Asian Australian Leadership Award (Basic Scientist, 2019), among others.

Session chair

Hong Yong Peh
National University Of Singapore

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Chengxue Helena Qin
Monash University

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