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Symposium 6: International Clinical and Translational Pharmacology Research to Inform Deprescribing in Old Age

Tracks
Track 6
Tuesday, July 14, 2026
11:15 AM - 1:15 PM

Details

This symposium, led by the Geriatric Committee of the IUPHAR Clinical and Translational Section, highlights international, interdisciplinary, clinical and translational pharmacology innovations to inform deprescribing in older people. Dr Reeve (EMCR pharmacist, chair ADeN, Australia) will discuss progress in evidence synthesis and deprescribing guidelines. Prof Steinman (geriatrician, chair USDeN, USA) will highlight work by USDeN to build capacity in patient centred deprescribing. Prof Thurmann (clinical pharmacologist, Germany) will discuss innovations in design, conduct and interpretation of deprescribing clinical trials. Dr Hayes (EMCR pharmaco-epidemiologist, chair ISPE Geriatric SIG, USA) will describe findings from an ISPE Geriatric SIG-funded systematic review and consensus paper on methodological guidance for real world evidence to guide deprescribing. Dr Mach (EMCR pharmacologist, ASCEPT, Australia) will outline the role of basic pharmacology and pre-clinical models to understand mechanisms and inform deprescribing.


Speaker

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Dr Emily Reeve
Monash University

Progress in evidence synthesis and deprescribing guidelines

Abstract

Biography

Dr Emily Reeve is a Senior Research Fellow and Deputy Director of the Centre for Medicine Use and Safety at Monash University in Melbourne, Australia. She is currently supported by an NHMRC Emerging Leader Investigator Grant. Dr Reeve is a qualified pharmacist with experience working as a clinical pharmacist in a large tertiary teaching hospital. Her research focuses on optimising medication use through “deprescribing” and she is Chair of the Australian Deprescribing Network (ADeN).
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Prof Michael Steinman
University of California, San Francisco and San Francisco VA Medical Center

Building capacity in patient-centred deprescribing: Insights from the US Deprescribing Research Network

Abstract

Biography

Dr. Steinman is a Professor of Medicine in the Division of Geriatrics at the University of California, San Francisco and the San Francisco VA Medical Center. A geriatrician-researcher, he cares for older adults in outpatient and inpatient settings and conducts research evaluating how older adults use medications, the problems that arise from medication overuse and misuse, and strategies for improving pharmaceutical care for older adults. He is co-principal investigator of the US Deprescribing Research Network, co-Director of the UCSF Pepper Center for Aging Research, and co-chair of the American Geriatrics Society Beers Criteria of Potentially Inappropriate Medications in Older Adults.
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Prof. Dr. Petra Thürmann
Chair
University Witten/Herdecke

Innovations in design, conduct and interpretation of deprescribing clinical trials.

Biography

Prof. Dr. Petra A. Thürmann, MD, is Director of the Philipp Klee-Institute of Clinical Pharmacology, Helios University Clinic Wuppertal, Germany. Since 2021 she is Vice-President of the University of Witten/Herdecke. After studies of Medicine at the Johann Wolfgang Goethe-University in Frankfurt/Main she received a board certified specialist’s degree in Clinical Pharmacology in 1992 and PhD (Habilitation) in 1997. In 1997 appointment at the HELIOS University Clinic in Wuppertal and 1998 at the University of Witten/Herdecke. Petra Thürmann was member of the Executive Committee of IUPHAR between 2004 and 2018. She is member of the Drug Commission of the German Medical Association, served from to 2011 until 2023 at the Advisory Council on the Assessment of Developments in the Health Care System (German Ministry of Health) and belongs since 2023 to the Expert Advisory Council “Health and Resilience” of the Federal Government of Germany. Her research interest is focused on geriatric pharmacotherapy (e.g. PRISCUS list), drug therapy safety as well as gender medicine.
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PharmD, PhD Kaley Hayes
Assistant Professor
Brown University

REporting and Methodological Recommendations for Observational Studies Estimating the effects of Deprescribing medications: the International Society for Pharmacoepidemiology-endorsed REMROSE-D Guidance

Abstract

Biography

Dr. Kaley Hayes is a pharmacoepidemiologist whose research mission is to apply rigorous pharmacoepidemiologic methods to understand how to use medications and vaccines to improve the health of older adults. She earned her PharmD at the University of Pittsburgh and her PhD in Epidemiology at the University of Toronto. Dr. Hayes conducts research using advanced pharmacoepidemiologic designs and causal inference methods to study outcomes among older patients with multiple chronic conditions to understand the benefits and potential harms of medications and vaccines in this vulnerable population.
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Dr John Mach
Research Fellow and Laboratory Manager
Kolling institute, USYD & NSLHD

Basic pharmacology to understand mechanisms and inform deprescribing

Abstract

Biography

Dr John Mach (BScMed(Hons), PhD) is a Research Fellow and Laboratory Manager who leads the basic science branch of the Laboratory of Ageing and Pharmacology, Kolling Institute, University of Sydney and Royal North Shore Hospital. His research applies basic science techniques to samples from preclinical and clinical studies to understand the mechanisms by which chronic medication exposure, polypharmacy and deprescribing cause beneficial and harmful effects in old age. His research aims to inform optimal medication use and deprescribing for older people.

Session chair

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Sarah Hilmer
Kolling Institute, Royal North Shore Hospital, NSLHD and University of Sydney

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Emily Reeve
Monash University

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