Wednesday, July 15, 2026

11:15 AM - 1:15 PM

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Details

G protein-coupled receptors (GPCRs) were traditionally viewed as plasma membrane delimited receptors, however, there is increasing evidence that these receptors can also signal from intracellular locations. Some receptors induce distinct responses at the plasma membrane compared to after their internalisation and trafficking to intracellular organelles such as the endosomal network and the Golgi apparatus. GPCRs can also exist at intracellular organelles in situ without first trafficking from the plasma membrane, where they initiate distinct cellular responses compared to stimulation of plasma membrane receptors. This spatial organisation of signalling is a mechanism that allows GPCRs to couple to a finite set of intracellular signalling pathways but initiate distinct cellular responses. This symposium will explore the latest knowledge in the regulation of sub-cellular cAMP signalling by GPCRs.

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Session chair