Tuesday, July 14, 2026

11:15 AM - 1:15 PM

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Details

Various types of injury in any organ activates repair mechanisms that often result in fibrosis. Fibrosis is the imbalance of excessive synthesis of extracellular matrix (ECM) proteins including enzymes that stabilize their structure and ECM degrading enzymes. Consequently, the stiff extracellular matrix reduces the function of organs and the progression of the diseases will ultimately lead to death by suffocation, heart, liver or kidney failure. In addition, ECM accumulation in solid cancers prevents effective chemo- or immunotherapy. Few unselective anti-fibrotics have been approved with substantial side effects. However, novel anti-fibrotics are currently in development that benefit from an increased knowledge of fibrotic pathways, a targeted approach and a cleaner side effect profile and improved tolerability and safety. Here, a US expert in fibrosis will review the landscape followed by presentations on adjuvant treatments in cancer, skin scaring and fibrosis.

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