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Symposium 3: Novel Anti-fibrotics: from pre-clinical proof of concept to clinical efficacy

Tracks
Track 3
Tuesday, July 14, 2026
11:15 AM - 1:15 PM

Details

Various types of injury in any organ activates repair mechanisms that often result in fibrosis. Fibrosis is the imbalance of excessive synthesis of extracellular matrix (ECM) proteins including enzymes that stabilize their structure and ECM degrading enzymes. Consequently, the stiff extracellular matrix reduces the function of organs and the progression of the diseases will ultimately lead to death by suffocation, heart, liver or kidney failure. In addition, ECM accumulation in solid cancers prevents effective chemo- or immunotherapy. Few unselective anti-fibrotics have been approved with substantial side effects. However, novel anti-fibrotics are currently in development that benefit from an increased knowledge of fibrotic pathways, a targeted approach and a cleaner side effect profile and improved tolerability and safety. Here, a US expert in fibrosis will review the landscape followed by presentations on adjuvant treatments in cancer, skin scaring and fibrosis.


Speaker

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Dr Jessica Chitty
Garvan Institute of Medical Research

A first in class pan-lysyl oxidase inhibitor in combination with chemotherapy significantly improves response to therapy and decreases metastasis in pancreatic cancer

Biography

Dr. Jessica L. Chitty is a Senior Postdoctoral Research Officer at the Garvan Institute of Medical Research, where she works in the Matrix and Metastasis Lab. She holds a Bachelor of Science in Biochemistry from the University of Sussex and completed her PhD at the University of Queensland, where she investigated novel drug targets in fungal pathogens within the fungal pathogenesis laboratory. Since joining the Garvan Institute in 2017, Dr. Chitty has focused on understanding and targeting the fibrotic tumour microenvironment in pancreatic ductal adenocarcinoma (PDAC). Her research explores the role of copper-dependent enzymes in driving tumour fibrosis and resistance to therapy. She has led preclinical studies on a novel pan-LOX inhibitor, SNT-5505, demonstrating its ability to reduce tumour stiffness, limit cancer cell invasion, and improve survival in mouse models of PDAC. Dr. Chitty has received several early-career awards, including the Matrix Biology ANZ Paper of the Year. She is also the Chief Investigator on a Cancer Council NSW project grant, supporting the advancement of anti-stromal therapies that target copper-dependent pathways in pancreatic cancer.
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A/Prof Mark Fear
University of Western Australia

Targeting scarring and fibrosis with novel irreversible inhibitors of Lysyl Oxidases

Abstract

Biography

A/Prof Fear (MA, Oxon) graduated from Oxford University in 1996, subsequently working at Northwestern University, USA before completing their PhD in non-melanoma skin cancers in 2003 at the University of London. Subsequently A/Prof Fear worked for Phylogica (now PYC therapeutics, ASX:PYC) in Perth, Australia until rejoining academia and working with Prof Fiona Wood in burn injury, skin repair and scarring in 2007. In addition to over 100 research publications, A/Prof Fear has extensive industry collaborations, focused on developing therapeutics and technologies for wound repair, scarring and fibrotic disorders.

Session chair

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Jian Gao
Shanghai Children’s Medical Center, School Of Medicine, Shanghai Jiao Tong University

Ashleigh Philp
Centenary Institute

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