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Symposium 19: Neurotransmitter Transporters: Structure, Function and Role in Human Disease

Tracks
Track 3
Thursday, July 16, 2026
11:15 AM - 1:15 PM

Details

Extracellular concentrations of neurotransmitters are regulated by transporter proteins, the dysfunction of which can trigger severe medical disorders (e.g. epilepsy, Parkinson’s, psychiatric and substance use disorders). Dr. Daws will discuss organic cation transporter 3 as a novel target for development of therapeutics for alcohol and amphetamine-type substance use disorders. Dr. Gether will describe genetic mouse models of dopamine transporter disease-linked mutants and how genetically encoded biosensors, fiber photometry, machine learning and pharmacological manipulations can be used to dissect pathobiological mechanisms. Dr. Sucic will describe how small molecules and pharmacochaperoning can rescue misfolded disease variants of human dopamine, creatine and GABA transporters. Dr. Sauer will present his cutting-edge research on the sodium/imino-acid transporter 1 and propose a model for its preference of secondary amino acids and transport cycle. Dr. Cater will describe how sophisticated membrane protein biochemistry, cryo-EM and biophysics collectively unravel the molecular mechanisms of transport at the blood-brain barrier.


Speaker

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Prof Lynette Daws
University of Texas Health Science Center at San Antonio

Unfaithful transporters: Insights into mechanisms of action of therapeutic and abused drugs

Abstract

Biography

Dr. Daws is a native of Australia, earning her PhD from the Flinders University of South Australia. She currently holds the Frost Bank Distinguished Professorship in Biomedical Sciences, in the Department of Cellular and Integrative Physiology at the University of Texas Health Science Center at San Antonio, and is Director of the Physiology and Pharmacology discipline in the Integrated Biomedical Sciences graduate program. Her research focuses primarily on monoamine transporters, and how they are involved in psychiatric and substance use disorders. One of her major contributions to this field is identification of organic cation transporters as important regulators of monoamine neurotransmission in brain, and as novel targets for the treatment of these disorders. Dr. Daws has published over 100 peer reviewed articles, reviews and book chapters, and has been continuously funded by the National Institutes of Health (NIH), as well as private foundations throughout her career. She has served on many national and international scientific review panels. She is a Fellow of the American College of Neuropsychopharmacology (ACNP) and of the American Society for Pharmacology and Experimental Therapeutics (ASPET). She served as Chair of the Neuropharmacology Division of ASPET and is a member of ASPET’s Publications Committee. She served as President of the International Society for Serotonin Research (ISSR). She was co-founder of the International Transmembrane Transporter Society (ITTS) and served as President. Dr. Daws is currently Editor-in-Chief of Pharmacological Reviews.
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Prof Ulrik Gether
Department of Neuroscience, University of Copenhagen

Mouse models of atypical dopamine transporter deficiency syndrome: exploiting genetically encoded biosensors to dissect disease-associated dopamine dysfunction

Abstract

Biography

Ulrik Gether (UG) is Professor of Molecular Neuropharmacology in Department of Neuroscience at University of Copenhagen (UCPH). UG obtained his MD from UCPH in 1990 and worked for three years as a research fellow at UCPH before carrying out his postdoctoral work at Stanford University. In 1996 Ulrik received the Ole Roemer Award enabling him to start his own laboratory back at UCPH. In 2001, he was appointed full professor at UCPH, and from 2017 to 2025 he was Head of Department of Neuroscience. UG’s research team has long-standing expertise in studying the monoamine system with focus on the physiological function and pharmacology of monoamine receptors and transporters. Lately, the work has explored how genetic variations in monoamine transporters contribute to disease, including the development of knock-in mice carrying disease-associated mutations to model monoamine-related pathologies. The team was the first to show that dopamine transporter (DAT) missense mutations can give rise to both psychiatric disease and early-onset parkinsonism. In recent years, UG has moreover employed genetically encoded monoamine sensors together with multiregion fiber photometry and machine learning to link cellular mechanisms and monoaminergic circuits to behavioral output and understand how these are affected in diseases states. Parallel efforts have involved use of several super-resolution microscopy techniques to study the molecular architecture of dopaminergic neurons. UG has published more than 200 peer-reviewed papers and served on numerous committees and boards.
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Assoc Prof Sonja Sucic
Medical University of Vienna

Functional rescue of GABA transporter 1 disease variants by pharmacochaperoning

Abstract

Biography

Sonja currently works as Associate Professor at the Institute of Pharmacology, Medical University of Vienna, Austria. She received both her Undergraduate Degree with First Class Honours (in Biotechnology and Drug Design and Development), and her PhD (in Pharmacology), from the University of Queensland, Brisbane, Australia. Her research focuses on rare, loss-of-function disease variants in neurotransmitter transporters of the solute carrier 6 (SLC6) protein superfamily. Sonja and her team investigate both the physiological repercussions and the underlying molecular basis (e.g. structural and/or protein folding/trafficking defects) of SLC6 pathogenic mutations. Dozens of such mutants have recently been linked to severe, and as yet untreatable, neurological disorders in children, e.g. epilepsy, infantile/juvenile parkinsonism-dystonia & intellectual disability. The main objective of this work is to discover new therapeutic avenues, needed for the functional rescue of these disease variants, by means of pharmacochaperoning using small molecules, known as chemical and pharmacological chaperones/allosteric modulators.
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David Sauer, PhD, PI
Centre for Medicines Discovery, University of Oxford

Role of SIT1 (SLC6A20) in transporting proline and neurotransmitters

Abstract

Biography

David Sauer is a biophysicist and Principal Investigator at the University of Oxford’s Centre for Medicines Discovery, focusing on the structure and function of membrane channels and transporters. He completed his PhD degree with Youxing Jiang at the University of Texas Southwestern Medical Center, studying potassium channel structure and ion selectivity. This was followed by postdoctoral training with Da-Neng Wang at New York University School of Medicine, describing the structure, transport mechanism, and chemical inhibition of SLC13/DASS membrane transporters. Since joining Oxford in 2021, David has led a group studying membrane proteins' function, pathogenesis, and chemical targeting by small molecules. His team’s results have revealed the amino acid import by SIT1 and CAT1, the reaction mechanism and inhibition of the ceramide synthase CerS6, and the pathogenic mechanisms of the muscle-type Acetylcholine Receptor nAChR.
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Rosemary Cater, PhD, Pl
Institute for Molecular Bioscience, University of Queensland

Structural and molecular basis of choline uptake into the brain by FLVCR2

Abstract

Biography

Rosemary Cater fulfilled her Ph.D. at the University of Sydney from 2013-2017 under the supervision of Prof. Renae Ryan. Here she used electrophysiology and x-ray protein crystallography to understand how glutamate transporters serve a secondary function as chloride channels. From 2017-2023, Dr. Cater worked as a Post-Doctoral Fellow in the laboratory of Prof. Filippo Mancia at Columbia University in New York City. Here she used single-particle cryo-electron microscopy and antigen-binding technology to determine structures of small membrane proteins. In January 2024, Dr. Cater was recently recruited to UQ's Institute for Molecular Bioscience as a Senior Research Fellow and Group Leader, where she currently holds an ARC DECRA fellowship. Her lab utilizes membrane protein biochemistry, cryo-EM, and biophysics to understand some of the brain’s most elusive yet important proteins. The overarching goal of the Cater Lab is to understand molecular mechanisms of transport at the blood-brain barrier.

Session chair

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Lynette Daws
University of Texas Health Science Center at San Antonio

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Sonja Sucic
Medical University of Vienna

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