Oral Presentations 11: Neuropharmacology 2
Tracks
Track 3
| Tuesday, July 14, 2026 |
| 2:30 PM - 4:00 PM |
Speaker
Ms Nicole Rudi
University Of Cambridge
Mr Jackson Kos
Monash University
Dr Maria Roznovcova
University of Reading
Dr Shane Hellyer
Monash Institute Of Pharmaceutical Sciences
Metabotropic glutamate receptor 5 negative allosteric modulators display sex-dependent properties.
Biography
Dr Hellyer is an EMCR researcher at the Monash Institute of Pharmaceutical Sciences, and it Deputy lab head of the Neuropharmacology lab within Drug Discovery Biology. His works focuses on the molecular pharmacology of GPCRs involved in neurophysiology and neuropathophysiology. In particular, Dr Hellyer is interested in the impact of single nucleotide variants found in patients populations, how they contribute to disease aetiology and how they potentially affect drug action on through changing receptor function. Dr Hellyer has published 21 peer reviewed journal articles and 1 book chapter, acting as a Chief Investigator on competitive grants worth $1.4 million.
Mr Shreyash Santosh Yadav
Phd Scholar
National Institute Of Pharmaceutical Education And Research Raebareli, India
Diet-Stress Interplay Impairs Synaptic Plasticity via MMP-9-Nectin Signalling
Biography
Shreyash Santosh Yadav is a Ph.D. Research Scholar in the Laboratory of Molecular NeuroTherapeutics at the National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, India. His research focuses on how metabolic and psychological stressors converge to disrupt synaptic plasticity, with a specific emphasis on MMP-9-mediated cleavage of nectin-1 and nectin-3 in hippocampal and prefrontal circuits. He has worked extensively across behavioural neuroscience, neuropharmacology, molecular biology, nanotechnology-based drug delivery, and neuropathology, collaborating on multidisciplinary projects involving AD, PD, metabolic stress, and CNS tissue architecture.
He has co-authored publications in journals such as ACS Chemical Neuroscience, ACS Biomaterials Science & Engineering, ChemistrySelect, Food Bioscience, and Acta Biomaterialia, and contributed to high-impact translational and structural neuroscience studies (including a manuscript under review at Nature Neuroscience). His work includes first-author or equal-contribution papers on neurodegeneration, diabetes therapeutics, biomimetic drug-delivery systems, and the nectin interactome. He has also contributed to a validation study of Clara Mater: The 4th meningeal layer in the human CNS.
Shreyash is a recipient of multiple accolades, including an EMCR Travel Grant, an ISN, IBRO, and ANRF-supported Travel Award, and a 3rd Position Oral Presentation at ICRANND-2025, MLSU, Udaipur, India, as well as the Best Oral Presentation Award at ICNAND-2023, Madhya Pradesh, India. His broader skill set encompasses stereotaxic surgery, immunofluorescence and confocal imaging, qRT-PCR, Western blotting, behavioural assays, cell culture, LC-MS/MS pharmacokinetics, and AI/data science-assisted analytics.