Symposium 32: Pharmacological advances in non-hormonal male contraceptive research to address global challenges
Tracks
Track 8
Friday, July 17, 2026 |
11:15 AM - 1:15 PM |
Details
There are over 200 million pregnancies globally each year and 121 million of these are unwanted. Increased options for contraception would almost certainly decrease the number of unwanted pregnancies. There is clearly a need to develop additional methods of contraception for males, an area of research that has been a major medical challenge for many years. Most strategies have focussed on hormonal strategies, however the problem with hormonal approaches is that they have intolerable side effects such as affecting libido, sexual performance and the development of masculine characteristics.
This symposium will bring together speakers from a range of disciplines contributing to male contraceptive research. Speakers will share their discoveries on novel targets for male contraception including the structure and pharmacology of the P2X1-purinergic receptor and the remodelling of sperm cells that affect motility. The symposium will apply a global health lens to research findings, highlighting existing challenges and emerging solutions.
Speaker
Dr Felix Bennetts
Monash Institute of Pharmaceutical Sciences, Monash University
Structure-Function Guided Development of P2X1 Receptor Small Molecule Antagonists for Use as a Non-Hormonal Male Contraceptive
Biography
Felix Bennetts is a Research Fellow at the Monash Institute of Pharmaceutical Sciences, Monash University, working under the supervision of Associate Professor David Thal and Dr. Sabatino Ventura. He completed his PhD in October 2024, with a focus on the structural and functional characterisation of the P2X1 receptor. Felix’s current research aims to therapeutically target the P2X1 receptor for the development of non-hormonal, oral male contraceptives. With support from the Male Contraceptive Initiative, his research advances drug discovery efforts to identify and optimise potent P2X1 receptor compounds for future clinical use. Beyond this, Felix has a broader interest in membrane proteins, applying structural biology and pharmacology to uncover druggable sites and guide small molecule drug design.
Dr Jessica Dunleavy
University of Melbourne
Bending sperm - targeting osmoregulation for contraception
Biography
Dr Jess Dunleavy is an ARC DECRA Fellow in the Male Infertility and Germ Cell Biology lab (led by Prof. Moira O’Bryan) at the BIO21 Institute and School of Biosciences at The University of Melbourne. Her research focuses on understanding the fundamental mechanisms that drive mammalian sperm production and function.
Jess begun her research career working under the supervision of Prof. Neil Gemmell and Dr Sheri Johnson at the University of Otago (NZ), studying the effect of paternal age on fertility in Zebrafish. She then completed her PhD at Monash University in 2018 supervised of Prof. Moira O'Bryan and Prof. John Carroll, wherein she defined the essential functions of the microtubule severing protein KATNAL2 in sperm production. As a research fellow, her research has continued to focus on the cell biology of sperm production and function. This includes defining the unique reliance male fertility has on microtubule severing and non-canonical tubulin proteins, and current projects on mitochondrial sheath development and microtubule glutamylation in male germ cell development. With the support of the Male Contraceptive Initiative (USA), she is also currently characterising a novel sperm specific regulator of osmoregulation, which has the has the potential to be an exciting contraceptive target.
Steve Kretschmer
Founder, Executive Director
DesireLine
Assessment of demand for male contraceptives: a multi-country study
Biography
Steve Kretschmer is a pioneer in global demand research for novel contraceptive technologies, with nearly 30 years of experience bridging healthcare market research and global development. As founder of DesireLine, he leads interdisciplinary teams applying behavioral science, data science, and human-centered design to shape health solutions that align with real-world user needs, especially in reproductive health, HIV, and health system strengthening.
Steve is also CEO of Sacyl Pharmaceuticals, a biotech developing first-in-class, non-hormonal, on-demand contraceptives. He has led the largest global study to date on male contraceptive demand, covering both LMICs and the U.S., and has advised donors, governments, and implementers on strategy and demand forecasting. His work informs investment, product design, and policy for equitable access to modern contraceptive methods.
He holds an MBA from The Pennsylvania State University and a B.A. in Philosophy from Thomas Aquinas College.
Heather Vahdat
Male Contraceptive Initiative
Advancing Male Contraception: Innovation, Market Potential, and Public Health Impact
Biography
Session chair
Heather Vahdat
Male Contraceptive Initiative
Sabatino Ventura
Monash University
